Make the Most of Your Summer with These 10 Fun Activities
**Heart Medications Show Limited Benefit in Duchenne Muscular Dystrophy Patients**
A recent study published in *Journal of Cardiology* examined the use of prophylactic cardiac drugs in combination for patients with Duchenne Muscular Dystrophy (DMD). The study aimed to determine whether a combination of perindopril and bisoprolol provided better outcomes compared to an ACE-inhibitor alone.
Researchers followed 65 participants for a total of 60 months, monitoring changes in left ventricular ejection fraction (LVEF) from baseline according to original randomization. Despite an initial trend favoring earlier initiation of therapy, there was no significant difference in LVEF between the two groups after 60 months. Both groups experienced a decrease in LVEF values, with more patients in the placebo group showing signs of ventricular dysfunction and requiring additional heart medications.
While some individuals may have benefited from earlier initiation of perindopril and bisoprolol, overall group-mean ventricular function did not differ significantly between study arms. The authors note that limitations such as small sample size, lack of a control group, and additional drug use may have impacted the results.
This study suggests that the use of heart medications in DMD patients may have limited benefits in preventing cardiomyopathy. Clinicians should consider individualized treatment plans based on patient characteristics and further research in this area.
#Kardiologi
Læs orginal abstract og artikel via Pubmed
*Disclaimer: AI baseret tekst, der har taget udgangspunkt i artiklen abstract. Teksten er derfor ikke egnet til at danne grundlag for fx. kliniske beslutninger. Tanken er snarere at give læseren lyst til at gå til kilde-teksten, og blive klogere.
