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Title: Adjuvant Chemotherapy with mFOLFOX6 after Lung Metastasectomy for Colorectal Cancer Shows Promise
Introduction: A recent phase 2 study evaluated the efficacy of adjuvant chemotherapy with modified 5-fluorouracil/leucovorin and oxaliplatin (mFOLFOX6) following lung metastasectomy in patients with colorectal cancer.
Journal: The study was published in the Journal of Clinical Oncology.
Study Design: Eligible patients had colorectal adenocarcinoma, underwent curative resection of ≤4 lung metastases, and had not received prior chemotherapy. Treatment consisted of 12 cycles of mFOLFOX6.
Key Findings: Of the 48 patients analyzed, the median age was 62 years. The majority had a good performance status and normal carcinoembryonic antigen levels. The study found that adjuvant chemotherapy with mFOLFOX6 after lung metastasectomy was feasible. The 5-year overall survival rate exceeded the threshold of 35%, demonstrating potential effectiveness in this setting.
Conclusion: Adjuvant chemotherapy with mFOLFOX6 may be a viable option for patients with colorectal cancer after lung metastasectomy. Further research is needed to confirm these promising results and determine the optimal treatment strategy for this patient population.
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